Brain PET originally started as a quantitative technique to investigate brain metabolism and blood flow. While compared to today’s standards the studies performed in the early days would be considered technically very simple, they revolutionized our understanding of brain function as related to health, disease and personality, with related health and social impact. Rapid advancements in detector technology, PET tracer development and data processing algorithms, facilitated by increasing computing power, led to increasingly more accurate and selective imaging of specific neurochemical targets and processes. More advanced image analysis methods are now shedding new light on neurochemical connectivity and its interplay with functional and structural networks revealing the complexity of brain function and hopefully identifying new therapeutic targets for several devastating brain disorders. This talk will discuss this fascinating journey emphasizing the interplay between scientific discoveries and developments in instrumentation and data analysis and how their synergies are opening news fields of investigation and ultimately facilitate clinical applications. Co-sponsored by: TRIUMF Speaker(s): Dr Vesan Sossi, Room: Auditorium, Bldg: Main office Building, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A3, Virtual: https://events.vtools.ieee.org/m/334718